TABLE 4.

List of miRNA-related POI studies.

miRNAs	Association with POI	Reference
miR-146 miR-196a2	Putative gene-gene interaction between miR-146 and miR-196a2 may be involved in POF development of Korean women.	Rah et al., 2013
	MiR-146aC > G and miR-196a2T > C change the mRNA expression patterns in granulosa cells.	Cho et al., 2017
miR-146	The expression of miR-146a in plasma and in ovarian granulosa cells of patients with POI was significantly upregulated.	Chen et al., 2015
miR-23a	Mir-23a may play important roles in regulating apoptosis via decreasing XIAP expression in human ovarian granulosa cells of POI patients.	Yang et al., 2012
miR-22-3p	The decreased expression of miR-22-3p in plasma of POI patients may reflect the diminished ovarian reserve and be a consequence of the pathologic process of POI.	Dang Y. et al., 2015
miR-379-5p	MiR-379-5p, PARP1, and XRCC6 were differentially expressed in granulosa cells of biochemical POI.	Dang et al., 2018
miR-21	Low expressions of miR-21 and Peli1 were detected in autoimmune POI mice and patients.	Li et al., 2020
miR-127-5p	The upregulation of miR-127-5p was also detected in plasma of bPOI (biochemical POI) individuals.	Zhang et al., 2020