TABLE 5.

Chemical and peptide-induced animal model of POI.

Chemical, dose, and duration	Reference
Cyclophosphamide (120 mg/kg), a single i.p. injection for 2 weeks*	Nguyen et al., 2019; Ding et al., 2020a
Busulfan (20 mg/kg) or (12 mg/kg) and cyclophosphamide (70 mg/kg) or (200 mg/kg), a single i.p. injection for 2 weeks*	Mohamed et al., 2018; Yang et al., 2019
Murine ZP3 330–342 peptides (NSSSSQFQIHGPR) (1 mg/mL), injection twice every 2 weeks* (autoimmune POI model)	Li et al., 2020
cisplatin (5 mg/kg), a single i.p. injection for 2 weeks*	Nguyen et al., 2019

*Dose and time of injection vary between studies.