Table 2.
Multivariate analysis of prognosis for distant metastasis of HCC.
| Variable | Overall Survival | Cancer-specific Survival | ||
|---|---|---|---|---|
| HR(95%CI) | P | HR(95%CI) | P | |
| Age(years) | ||||
| 18-51 | 1.000(Reference) | 1.000(Reference) | ||
| 52-72 | 1.132(1.003-1.277) | 0.045 | 1.150(1.015-1.303) | 0.028 |
| 73-96 | 1.199(1.043-1.380) | 0.011 | 1.212(1.049-1.400) | 0.009 |
| Gender | ||||
| Male | 1.000(Reference) | 1.000(Reference) | ||
| Female | 0.881(0.800-0.971) | 0.011 | 0.873(0.790-0.966) | 0.008 |
| Grade stage | ||||
| I+II | 1.000(Reference) | 1.000(Reference) | ||
| III+IV | 1.503(1.315-1.717) | 0.000 | 1.510(1.318-1.729) | 0.000 |
| Unknown | 1.120(1.018-1.232) | 0.020 | 1.103(1.000-1.216) | 0.050 |
| T stage | ||||
| T0 | 1.000(Reference) | 1.000(Reference) | ||
| T1 | 0.752(0.440-1.287) | 0.299 | 0.785(0.450-1.371) | 0.395 |
| T2 | 0.897(0.523-1.538) | 0.692 | 0.918(0.525-1.605) | 0.763 |
| T3 | 0.960(0.561-1.641) | 0.881 | 1.011(0.579-1.763) | 0.970 |
| T4 | 0.976(0.566-1.684) | 0.931 | 1.037(0.589-1.825) | 0.901 |
| TX | 0.756(0.438-1.307) | 0.317 | 0.804(0.456-1.417) | 0.450 |
| N stage | ||||
| N0 | 1.000(Reference) | 1.000(Reference) | ||
| N1 | 1.130(1.032-1.236) | 0.008 | 1.130(1.030-1.240) | 0.009 |
| Nx | 0.952(0.849-1.067) | 0.394 | 0.937(0.833-1.054) | 0.277 |
| Primary tumor surgery | ||||
| No | 1.000(Reference) | 1.000(Reference) | ||
| Local tumor destruction | 0.518(0.394-0.682) | 0.000 | 0.487(0.364-0.651) | 0.000 |
| Surgery | 0.421(0.323-0.548) | 0.000 | 0.386(0.295-0.505) | 0.000 |
| Metastatic surgery | ||||
| Yes | 1.000(Reference) | 1.000(Reference) | ||
| No | 1.206(1.009-1.441) | 0.039 | / | 0.053 |
| Radiotherapy | ||||
| Yes | 1.000(Reference) | 1.000(Reference) | ||
| No | 1.325(1.207-1.455) | 0.000 | 1.318(1.199-1.449) | 0.000 |
| Chemotherapy | ||||
| Yes | 1.000(Reference) | 1.000(Reference) | ||
| No | 1.660(1.540-1.790) | 0.000 | 1.607(1.488-1.736) | 0.000 |
| Tumor size | ||||
| ≤6 | 1.000(Reference) | 1.000(Reference) | ||
| >6 | 1.261(1.141-1.394) | 0.000 | 1.256(1.133-1.393) | 0.000 |
| Unknown | 1.365(1.204-1.547) | 0.000 | 1.365(1.200-1.553) | 0.000 |
| Metastatic site | ||||
| Bone only | 1.000(Reference) | 1.000(Reference) | ||
| Brain only | / | 0.456 | / | 0.498 |
| Lung only | / | 0.701 | / | 0.574 |
| Unknown | / | 0.218 | / | 0.271 |
| Number of metastases | ||||
| Single | 1.000(Reference) | 1.000(Reference) | ||
| Multiple | 1.221(1.066-1.399) | 0.004 | 1.253(1.091-1.438) | 0.001 |
| Unknown | 0.811(0.747-0.880) | 0.000 | 0.805(0.740-0.876) | 0.000 |
| Multiple organ metastasis | ||||
| Bone+brain | 1.000(Reference) | 1.000(Reference) | ||
| Bone+lung | / | 0.573 | / | 0.350 |
| Brain+lung | / | 0.469 | / | 0.254 |
| Bone+brain+lung | / | 0.829 | / | 0.834 |
| Unknown | / | 0.733 | / | 0.879 |