Table 3.
The relationship between different metastatic sites and clinical features (after PSM).
| Variable | Bone metastasis(n/%) | P(χ2) | Brain metastasis (n/%) | P(χ2) | Lung metastasis(n/%) | P(χ2) | |||
|---|---|---|---|---|---|---|---|---|---|
| Yes(n=687) | No(n=687) | Yes(n=63) | No(n=63) | Yes(n=1169) | No(n=1169) | ||||
| Age(years) | 0.604 | 0.235 | 0.174 | ||||||
| 18-51 | 60(8.7) | 65(9.5) | 8(12.7) | 15(23.8) | 145(12.4) | 116(9.9) | |||
| 52-72 | 506(73.7) | 492(71.6) | 48(76.2) | 35(55.6) | 788(67.4) | 836(71.5) | |||
| 73-96 | 121(77.6) | 130(18.9) | 7(11.1) | 13(20.6) | 236(20.2) | 217(18.6) | |||
| Race | 0.002 | 0.190 | 0.631 | ||||||
| White | 445(64.8) | 472(68.7) | 43(68.3) | 49(77.8) | 722(61.8) | 765(65.4) | |||
| Black | 148(21.5) | 109(15.9) | 11(17.5) | 5(8.0) | 210(18.0) | 200(17.1) | |||
| Other/unknown | 94(13.7) | 106(15.4) | 9(14.2) | 9(14.2) | 237(20.3) | 204(17.5) | |||
| Gender | 0.603 | 0.348 | 0.173 | ||||||
| Male | 582(84.7) | 564(82.1) | 50(79.4) | 53(84.1) | 930(80.0) | 943(80.7) | |||
| Female | 105(15.3) | 123(17.9) | 13(20.6) | 10(15.9) | 239(20.0) | 226(19.3) | |||
| Marital status | 0.751 | 0.153 | 0.535 | ||||||
| Married | 304(44.3) | 327(47.6) | 29(46.0) | 27(42.9) | 549(47.0) | 536(45.9) | |||
| Unmarried | 348(50.7) | 326(47.5) | 33(52.4) | 29(46.0) | 55947.8() | 578(49.4) | |||
| Other | 35(5.0) | 34(4.9) | 1(1.6) | 7(11.1) | 61(5.2) | 55(4.7) | |||
| Year of diagnosis | 0.516 | 0.269 | 0.868 | ||||||
| 2010-2012 | 324(47.2) | 333(48.5) | 27(42,9) | 28(44.4) | 540(46.2) | 530(45.3) | |||
| 2013-2015 | 363(52.8) | 354(51.5) | 36(57.1) | 35(55.6) | 629(53.8) | 639(54.7) | |||
| Grade stage | 0.940 | 0.022 | 0.382 | ||||||
| I+II | 129(18.8) | 118(17.2) | 19(30.2) | 12(19.0) | 214(18.3) | 240(20.5) | |||
| III+IV | 77(11.2) | 105(15.3) | 4(6.3) | 4(6.3) | 163(13.9) | 137(11.7) | |||
| Unknown | 481(70.0) | 464(67.5) | 40(63.5) | 47(74.7) | 792(67.8) | 792(67.8) | |||
| T stage | 0.000 | 0.011 | 0.518 | ||||||
| T0 | 7(1.0) | 3(0.4) | 2(3.1) | 0(0) | 6(0.5) | 3(0.3) | |||
| T1 | 138(20.1) | 115(16.7) | 20(31.7) | 14(22.2) | 233(19.9) | 208(17.8) | |||
| T2 | 84(12.2) | 74(10.8) | 7(11.1) | 7(11.1) | 124(10.6) | 125(10.7) | |||
| T3 | 260(37.8) | 283(41.2) | 14(22.2) | 29(46.0) | 428(36.6) | 481(41.1) | |||
| T4 | 42(6.1) | 86(12.5) | 3(4.8) | 5(8.0) | 152(13.0) | 126(10.8) | |||
| TX | 156(22.8) | 126(18.3) | 17(27.1) | 8(12.7) | 226(19.3) | 226(19.3) | |||
| N Stage | 0.022 | 0.730 | 0.000 | ||||||
| N0 | 450(65.6) | 424(61.7) | 46(73.0) | 35(55.6) | 749(64.1) | 704(60.2) | |||
| N1 | 132(19.2) | 163(23.7) | 10(15.9) | 13(20.6) | 230(19.7) | 318(27.2) | |||
| Nx | 105(15.2) | 100(14.6) | 7(11.1) | 15(23.8) | 190(16.3) | 147(12.6) | |||
| Primary tumor surgery | 0.600 | 1.000 | 0.763 | ||||||
| No | 663(96.5) | 655(95.3) | 60(95.2) | 60(95.2) | 1137(97.3) | 1138(97.3) | |||
| Local tumor destruction | 9(1.3) | 12(1.7) | 2(3.2) | 3(4.8) | 13(1.1) | 10(0.9) | |||
| Surgery | 15(2.2) | 20(3.0) | 1(1.6) | 0(0) | 19(1.6) | 21(1.8) | |||
| Metastatic Surgery | 0.303 | 0.593 | 0.714 | ||||||
| Yes | 43(6.3) | 42(6.1) | 9(14.3) | 5(8.0) | 33(2.8) | 39(3.3) | |||
| No | 644(93.7) | 645(93.9) | 54(85.7) | 5892.0() | 1136(97.2) | 1130(96.7) | |||
| Radiotherapy | 0.950 | 0.064 | 0.948 | ||||||
| Yes | 168(24.5) | 166(24.2) | 28(44.4) | 20(31.7) | 135(11.5) | 137(11.7) | |||
| No | 519(75.5) | 521(75.8) | 35(55.6) | 43(68.3) | 1034(88.5) | 1032(88.3) | |||
| Chemotherapy | 0.175 | 0.271 | 0.709 | ||||||
| Yes | 302(44.0) | 308(44.8) | 21(33.3) | 26(41.2) | 560(47.9) | 525(44.9) | |||
| No | 385(56.0) | 379(55.2) | 42(66.7) | 37(58.8) | 609(52.1) | 644(55.1) | |||
| Tumor size | 0.002 | 0.444 | 0.012 | ||||||
| ≤6 | 216(31.4) | 191(27.8) | 21(33.3) | 19(30.2) | 254(21.7) | 306(26.2) | |||
| >6 | 275(40.0) | 308(44.8) | 22(34.9) | 31(49.2) | 598(51.2) | 532(45.5) | |||
| Unknown | 196(28.6) | 188(27.4) | 20(31.8) | 13(20.6) | 317(27.1) | 331(28.3) | |||