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. 2021 May 10;8:661403. doi: 10.3389/fmed.2021.661403

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Copyright © 2021 Stocco, Belluzzi, Contran, Boscolo-Berto, Picardi, Guidolin, Fontanella, Olivotto, Filardo, Borile, Romanato, Ramonda, Ruggieri, Favero, Porzionato, De Caro and Macchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elastic fibers distribution. Van Gieson staining showed in violet the elastic fibers orientation around the adipocytes (A) (scale bar = 200 μm) and in correspondence of the septa (B) (scale bar = 50 μm) for ACL-IFPs and cadaver donors-IFPs. Quantification of the elastic fibers showed differences in the two settings. Significantly, higher elastic fibers were observed around the adipocytes in the ACL-IFPs (p = 0.021) (C) but not in correspondence of the septa in the cadaver donors-IFPs (p = 0.0872) (D). For the adipocytes surrounding areas, data analysis considered n = 12 and n = 23 tissue samples for ACL-IFPs and cadaver donors-IFPs, respectively; for the septa, data analysis considered n = 5 and n = 23 tissue samples for ACL-IFPs and cadaver donors-IFPs, respectively. AU, arbitrary unit.