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. 2021 May 10;8:661403. doi: 10.3389/fmed.2021.661403

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Copyright © 2021 Stocco, Belluzzi, Contran, Boscolo-Berto, Picardi, Guidolin, Fontanella, Olivotto, Filardo, Borile, Romanato, Ramonda, Ruggieri, Favero, Porzionato, De Caro and Macchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative picture between the two study groups, showing the tissutal specific features related to IFP physiological maturation, in case of the absence of carilage defect. The image highlights the main study findings with respect to the initial hypotheses which have been identified in the red (a. absence of inflammatory features in case of no cartilage lesions), green (b. variation in adipocytes area despite manteinence of the typical cells morphology with aging) and blue (c. reduction in extracellular matrix proteins and different distribution with aging) boxes, respectively. ACL, anterior cruciate ligament reconstruction; BMI; body mass index; Col, collagen; EF, elastic fibers; IFP, infrapatellar fat pad.