Figure 8.

In vivo tumor xenografts

(A) Nude mice bearing tumors, and a specimen from each respective group, are shown. Tumor volume was measured every 4 days after injection. Twenty-eight days later, the mice were sacrificed, and the tumors were excised and weighed (n = 3 per group). (B) Expression levels of HMGA2 and Ki-67. Positive cells are stained brown. Data are presented as the mean ± SEM (n = 3 per group). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 versus the control group, ^#p < 0.001 versus the agomir group, ^▴p < 0.001 versus the sh-MIR210HG group. (C) A working model showing the interaction between MIR210HG and the miR-337-3p/137-HMGA2 axis in Ishikawa and HEC-1A cells.