Table 3.
Results of support vector machine (SVM).
Brain volumetry | Clinical parameters | SVM parameters | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hippo | Accumbent | Amygdala | Caudate | Thalamus | White.M | Gray.M | Ventricle | TMSE | LM | COWA-animals | COWA-KSP | Clock | Conpraxis | NPI4 | NPI5 | NPI7 | NPI9 | NPI 1–12 | Setting | Trained set | Tested set | ||||||||||
C | Gamma | N | TP rate | FP rate | Accuracy | ROC | N | TP rate | FP rate | Accuracy | ROC | ||||||||||||||||||||
1 | x | 10 | 100 | 92 | 0.630 | 0.371 | 63.050 | 0.630 | 91 | 0.626 | 0.340 | 62.637 | 0.575 | ||||||||||||||||||
2 | x | 10 | 100 | 92 | 0.598 | 0.406 | 59.783 | 0.596 | 91 | 0.571 | 0.431 | 57.143 | 0.579 | ||||||||||||||||||
3 | x | 10 | 100 | 92 | 0.565 | 0.447 | 56.521 | 0.559 | 91 | 0.538 | 0.462 | 53.846 | 0.541 | ||||||||||||||||||
4 | x | 100 | 1 | 92 | 0.565 | 0.434 | 56.523 | 0.565 | 91 | 0.549 | 0.454 | 54.945 | 0.526 | ||||||||||||||||||
5 | x | 100 | 0.1 | 92 | 0.587 | 0.417 | 58.660 | 0.550 | 91 | 0.495 | 0.509 | 49.451 | 0.424 | ||||||||||||||||||
6 | x | 1 | 100 | 92 | 0.641 | 0.364 | 64.130 | 0.590 | 91 | 0.571 | 0.432 | 57.143 | 0.488 | ||||||||||||||||||
7 | x | 1 | 100 | 92 | 0.641 | 0.364 | 64.130 | 0.639 | 91 | 0.560 | 0.444 | 56.044 | 0.402 | ||||||||||||||||||
8 | x | 10 | 10 | 92 | 0.620 | 0.380 | 61.957 | 0.621 | 91 | 0.604 | 0.398 | 60.440 | 0.571 | ||||||||||||||||||
9 | x | x | 10 | 100 | 92 | 0.587 | 0.416 | 58.696 | 0.585 | 91 | 0.520 | 0.473 | 52.747 | 0.559 | |||||||||||||||||
10 | x | x | x | 100 | 100 | 92 | 0.620 | 0.381 | 61.950 | 0.619 | 91 | 0.495 | 0.505 | 49.450 | 0.550 | ||||||||||||||||
11 | x | x | x | x | x | x | x | 1 | 100 | 92 | 0.641 | 0.358 | 64.130 | 0.642 | 91 | 0.538 | 0.461 | 53.846 | 0.539 | ||||||||||||
12 | x | x | x | x | x | x | x | x | 100 | 0.1 | 92 | 0.598 | 0.406 | 59.783 | 0.596 | 91 | 0.510 | 0.430 | 57.143 | 0.560 | |||||||||||
13 | x | X | 100 | 0.01 | 55 | 0.764 | 0.233 | 63.640 | 0.765 | 54 | 0.704 | 0.296 | 70.370 | 0.822 | |||||||||||||||||
14 | x | 100 | 0.1 | 42 | 0.786 | 0.267 | 78.571 | 0.590 | 42 | 0.833 | 0.181 | 83.333 | 0.844 | ||||||||||||||||||
15 | x | x | 10 | 0.1 | 55 | 0.782 | 0.218 | 78.181 | 0.848 | 55 | 0.741 | 0.259 | 74.074 | 0.804 | |||||||||||||||||
16 | x | x | x | x | X | x | 100 | 1 | 55 | 0.891 | 0.109 | 89.091 | 0.891 | 54 | 0.907 | 0.093 | 90.741 | 0.955 | |||||||||||||
17 | x | x | x | x | x | X | x | 10 | 1 | 55 | 0.891 | 0.109 | 89.091 | 0.891 | 54 | 0.889 | 0.111 | 88.889 | 0.927 | ||||||||||||
18 | x | x | x | x | x | x | x | x | x | x | x | x | X | x | 100 | 1 | 55 | 0.927 | 0.073 | 92.727 | 0.927 | 54 | 0.907 | 0.093 | 90.741 | 0.925 | |||||
19 | x | x | x | x | x | 10 | 10 | 38 | 0.842 | 0.118 | 84.211 | 0.862 | 38 | 0.737 | 0.377 | 73.684 | 0.475 | ||||||||||||||
20 | x | 10 | 1 | 38 | 0.789 | 0.411 | 78.947 | 0.689 | 38 | 0.711 | 0.711 | 71.053 | 0.000 | ||||||||||||||||||
21 | x | 100 | 1 | 38 | 0.709 | 0.286 | 70.909 | 0.712 | 38 | 0.605 | 0.753 | 60.526 | 0.000 | ||||||||||||||||||
22 | x | 10 | 1 | 38 | 0.789 | 0.411 | 78.947 | 0.689 | 38 | 0.684 | 0.721 | 68.421 | 0.175 |
Hippo, hippocampus; LM, learning memory; COWA, controlled oral word association test (animals; and letters K, S, P); clock, clock drawing test; NPI4, depression; NPI5, anxiety; NPI7, apathy; NPI9, irritability; TP rate, true positive rate; FP rate, false positive rate; ROC, receiver operating characteristic; curve (stands for AUC—area under the curve—in this table). Blue = main flow; Yellow = subjects excluded; Green = action done to the data.