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. 2021 May 10;12:640696. doi: 10.3389/fneur.2021.640696

Table 3.

Results of support vector machine (SVM).

Brain volumetry Clinical parameters SVM parameters
Hippo Accumbent Amygdala Caudate Thalamus White.M Gray.M Ventricle TMSE LM COWA-animals COWA-KSP Clock Conpraxis NPI4 NPI5 NPI7 NPI9 NPI 1–12 Setting Trained set Tested set
C Gamma N TP rate FP rate Accuracy ROC N TP rate FP rate Accuracy ROC
1 x 10 100 92 0.630 0.371 63.050 0.630 91 0.626 0.340 62.637 0.575
2 x 10 100 92 0.598 0.406 59.783 0.596 91 0.571 0.431 57.143 0.579
3 x 10 100 92 0.565 0.447 56.521 0.559 91 0.538 0.462 53.846 0.541
4 x 100 1 92 0.565 0.434 56.523 0.565 91 0.549 0.454 54.945 0.526
5 x 100 0.1 92 0.587 0.417 58.660 0.550 91 0.495 0.509 49.451 0.424
6 x 1 100 92 0.641 0.364 64.130 0.590 91 0.571 0.432 57.143 0.488
7 x 1 100 92 0.641 0.364 64.130 0.639 91 0.560 0.444 56.044 0.402
8 x 10 10 92 0.620 0.380 61.957 0.621 91 0.604 0.398 60.440 0.571
9 x x 10 100 92 0.587 0.416 58.696 0.585 91 0.520 0.473 52.747 0.559
10 x x x 100 100 92 0.620 0.381 61.950 0.619 91 0.495 0.505 49.450 0.550
11 x x x x x x x 1 100 92 0.641 0.358 64.130 0.642 91 0.538 0.461 53.846 0.539
12 x x x x x x x x 100 0.1 92 0.598 0.406 59.783 0.596 91 0.510 0.430 57.143 0.560
13 x X 100 0.01 55 0.764 0.233 63.640 0.765 54 0.704 0.296 70.370 0.822
14 x 100 0.1 42 0.786 0.267 78.571 0.590 42 0.833 0.181 83.333 0.844
15 x x 10 0.1 55 0.782 0.218 78.181 0.848 55 0.741 0.259 74.074 0.804
16 x x x x X x 100 1 55 0.891 0.109 89.091 0.891 54 0.907 0.093 90.741 0.955
17 x x x x x X x 10 1 55 0.891 0.109 89.091 0.891 54 0.889 0.111 88.889 0.927
18 x x x x x x x x x x x x X x 100 1 55 0.927 0.073 92.727 0.927 54 0.907 0.093 90.741 0.925
19 x x x x x 10 10 38 0.842 0.118 84.211 0.862 38 0.737 0.377 73.684 0.475
20 x 10 1 38 0.789 0.411 78.947 0.689 38 0.711 0.711 71.053 0.000
21 x 100 1 38 0.709 0.286 70.909 0.712 38 0.605 0.753 60.526 0.000
22 x 10 1 38 0.789 0.411 78.947 0.689 38 0.684 0.721 68.421 0.175

Hippo, hippocampus; LM, learning memory; COWA, controlled oral word association test (animals; and letters K, S, P); clock, clock drawing test; NPI4, depression; NPI5, anxiety; NPI7, apathy; NPI9, irritability; TP rate, true positive rate; FP rate, false positive rate; ROC, receiver operating characteristic; curve (stands for AUC—area under the curve—in this table). Blue = main flow; Yellow = subjects excluded; Green = action done to the data.