Fig. 3.

Biomarker discovery from high throughput biological data using bioinformatic network models. These networks to some extent describe real biological interaction networks between the involved molecules in a disease aetiology. In the figure, such a network is exemplified as a network describing protein interactions and their abundance inside, in the membrane of, and outside cells. As can be seen, the resulting network has an internal structure: it contains hubs and clusters whose degree of abundance can be associated with a certain disease or treatment susceptibility.