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. 2021 Apr 28;51:101244. doi: 10.1016/j.molmet.2021.101244

Figure 7.

Figure 7

Pharmacological inhibition of miR-34a ameliorated liver steatosis. The C57BL/6 mice were fed an HFCF diet for a total of 16 weeks. In the last 5 weeks of the feeding study, the mice were i.p. injected with PBS, locked nucleic acids (LNA) against scramble sequences (LNA-Scr), or miR-34a (LNA-miR-34a) once a week (10 mg/kg). (A) Body fat content. (B) The ratio of liver weight to body weight. (C) Hepatic TC levels. (D) Hepatic FC levels. (E) Hepatic TG levels. (F) Hepatic FFA levels. (G) Hepatic mRNA levels. ∗∗P < 0.01.