Table 2.

Drug likeness parameters of compounds 5–17^a

Compd. no.	Formula	Molecular weight	NHBA	NHBD	LogP	TPSA, Å2	V, Å3	DLS
5	C16H14N2O6S	362.06	6	5	–0.57	114.29	307.29	–0.73
6	C17H16N2O3	296.12	3	4	2.76	71.87	288.83	–0.16
7	C19H18N2O5S	386.09	5	5	1.40	97.61	340.44	–0.19
8	C17H16N2O5S	360.08	5	4	0.72	96.76	317.25	–0.66
9	C19H18N2O6S	402.09	6	4	0.24	106.48	355.56	–0.17
10	C18H17N3O6S	403.08	7	4	–0.53	110.07	353.50	–0.27
11	C17H16N2O5S	360.08	5	4	0.82	97.63	317.22	–0.57
12	C18H18N2O5S	374.09	5	4	1.34	97.63	335.12	–0.69
14	C18H18N4O8S	450.08	10	5	–0.74	150.24	380.77	–0.79
15	C20H22N4O6S	446.13	8	3	1.18	117.64	399.55	–0.60
16	C20H20N4O7S	460.11	9	3	0.04	126.10	402.62	–0.23
17	C23H18N4O8S	510.08	10	5	1.01	155.40	434.50	0.06

^a NHBA is the number of hydrogen bond acceptor centers, NHBD is the number of hydrogen bond donor centers, LogP is the lipophilicity coefficient, TPSA is the topological polar surface area, V is the molecular volume, and DLS is the drug likeness score.