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. 2021 Apr 22;296:100705. doi: 10.1016/j.jbc.2021.100705

Figure 6.

Figure 6

Noncatalytic kinases as mediators and targets of inhibitors.A, illustration of the mechanism of viral MLKLs (dark gray), which compete with endogenous MLKL for binding to RIPK3 (blue). B, proposed interaction of IRAK3 pseudokinase homodimers binding to IRAK4 homodimers in an appropriate manner to suppress IRAK4 activity and potentially impede the assembly of higher-order IRAK4 activation at the Myddosome. Models derived from PDBs 6RUU and 4U97, as described in reference (39). Activation loops and αC-helices of IRAK3 and IRAK4 are shown.