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. 2021 Apr 22;296:100691. doi: 10.1016/j.jbc.2021.100691

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

MhCls activity in the presence of various alcohols I.A, glycerol-like alcohols: 1-propanol (1-PrOH), 2-propanol (2-PrOH), 1,2-propanediol (1,2-PrOH), 1,3-propanediol (1,3-PrOH), 1,2-ethanediol (1,2-EtOH), 1,3-butanediol (1,3-BuOH), 1,4-butanediol (1,4-BuOH), and mannitol. Lipid species are displayed as LC-MS chromatograms. B, schematic representation of all possible enzymatic reactions performed and products formed by MhCls, starting with glycerol-di-phosphatidyl-cardiolipin (Gro-DPCL) and a free alcohol containing two primary hydroxyl groups as substrates (left top). Reaction 1 and 6: hydrolysis of Gro-DPCL and alcohol-DPCL, respectively. Reactions 2, 3, 4, and 5: reversible transesterification of Gro-DPCL/alcohol-DPCL in the presence of glycerol/alcohol into P-alcohol/P-glycerol.