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lncMYH7b controls β-MyHC expression at both the RNA and protein level.A, MYH7b RNA decreases at least 48 h before there is a change in β-MyHC, RNA levels are reduced. B, ASOs targeted against MYH7b RNA do not affect myomiR levels. C, myosin-separating gels show a reduction in the β-/α-MyHC ratio at the protein level upon lncMYH7b KD in hiPS-CMs. D, representative myosin-separating gel.
