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lncMYH7b KD affects adrenergic signaling and beat rate in hiPS-CMs.A, KEGG pathway diagram showing the effects seen on adrenergic signaling genes upon lncMYH7b KD. B, hiPS-CMs treated with MYH7b ASO have a significantly slower spontaneous beat rate than those treated with control ASO. C, changes in RyR2 and PP2A expression shown by RNA-seq are recapitulated at the protein level.
