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View full-text article in PMC

. 2021 Apr 22;296:100694. doi: 10.1016/j.jbc.2021.100694

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

lncMYH7b KD causes significant effects on sarcomere organization in hiPS-CMs.A, representative images showing the three phenotypes of α-actinin staining we scored in hiPS-CMs. The “organized” category was broken down into two subphenotypes: organized sarcomeres and presarcomeres that have been shown to transition to fully organized sarcomeres in hiPS-CMs (36). This is in comparison to the disorganized phenotype, where there is no discernible organization of alpha-actinin. B, quantification of the change in α-actinin phenotype upon lncMYH7b knockdown. There is a significant decrease in the percentage of cells with α-actinin organization with MYH7b ASO treatment. Cells from three wells from two independent differentiations were scored.