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IHC evaluation of CS markers in PSC cases.
(A) Examples of a negative stain for p16 (original magnification 40×), (B) a diffuse nuclear and cytoplasmic p16 expression in both NBD and DR (original magnification 40×), and (C) a diffuse p21 nuclear expression, in both NBD and DR (original magnification 40×). CS, cellular senescence; DR, ductular reaction; IHC, immunohistochemical; NBD, native bile duct; p16, p16INK4A; p21, p21WAF1/Cip1; PSC, primary sclerosing cholangitis.
