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. 2021 May 20;20:15330338211011965. doi: 10.1177/15330338211011965

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Effect of membrane poration with ultrasound (US) on enhancement of anticancer drug delivery to cells. (A) The ability of the drug alone to cross the lipid membrane. (B) The proposed enhanced ability of the anticancer drug to cross the lipid membrane in combination with the use of US. (C) The anticancer drug-loaded microbubbles combining with US in the treatment of tumors. Anticancer drugs are attached to the surface of the microbubbles, encased inside the microbubbles, or embedded in the microbubble membrane.^37-39 After ultrasound irradiation, microbubbles are destructed in tumor cells and drugs carried by microbubbles are released into tumor cells.