Figure 2.

Four types of synaptic responses were observed in the ACC after TBS and LFS stimulation. (a–d) The sample temporal changes of fEPSP slopes with four types of plasticity from one the ACC slice. All recorded 16 channels were divided into four different types: 6 channels with type I (LTP + Depression) (a), 5 channels with type II (LTP + No-Depression) (b), 2 channels with type III (No-LTP + Depression) (c) and 3 channels with type IV (No-LTP + No-Depression) (d). Top: sample traces at 0 min (number 1), 30 min (number 2) and 75 min (number 3). (e) The pooled fEPSP slopes plot indicated the final averaged fEPSP slopes of all recorded channels, showing that LFS could induce synaptic depression after LTP induction within 30-min interval (n = 11 slices/9 mice). (f) Statistical results showed the last 10-min averaged fEPSP slopes from total activated channels at different time points (**p < 0.01, paired t-test). The dashed line indicated the mean basal synaptic responses.