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. 2021 May 22;17:17448069211018045. doi: 10.1177/17448069211018045

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — NMDA receptors were required for synaptic depression after synaptic potentiation in the ACC. (a) The summarized fEPSP slope plot showed that bath applied AP-5 (NMDA receptor antagonist, 50 µM) throughout the whole recordings blocked the induction of LTP and LTD (n = 7 slices/6 mice). (b) Statistical results showed that no difference of fEPSP slopes after TBS and LFS in the presence of AP-5. (c) The summarized fEPSP slope plot showed that AP-5 inhibited LFS-induced synaptic depression after TBS-induced LTP (n = 9 slices/7 mice). (d) Statistical results showed that the fEPSP slope was not decreased by LFS in the presence of AP-5 after TBS-induced LTP. (e) The network propagation of synaptic responses after AP-5 applied. Basal activated areas (blue), recruited areas (red) induced by TBS, and silent areas (yellow) induced by LFS in male mice, respectively. The recruited channels are shown as green dots and the silent channels are shown as purple dots. n.s. means no significant difference, error bars indicated SEM. (f) The percentage of activated channels for four different types of synaptic responses after AP-5 applied.