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. Author manuscript; available in PMC: 2021 May 24.
Published in final edited form as: Nat Rev Mol Cell Biol. 2021 Jan 25;22(4):266–282. doi: 10.1038/s41580-020-00324-8

Figure 1. An overview of ferroptosis.

Figure 1.

A schematic chart showing that ferroptosis is executed by phospholipid peroxidation, a process relying on metabolic products reactive oxygen species (ROS), phospholipid containing polyunsaturated fatty acid chain(s) (PUFA-PL), and transition metal iron, and that intra- and intercellular signaling events and environmental stresses can impact ferroptosis by regulating cellular metabolism and ROS level. The figure also shows the role of ferroptosis in disease and its potential physiological functions.