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. Author manuscript; available in PMC: 2021 May 24.
Published in final edited form as: Nat Rev Mol Cell Biol. 2021 Jan 25;22(4):266–282. doi: 10.1038/s41580-020-00324-8

Figure 4. Metabolism and cell signaling in ferroptosis.

Figure 4.

The figure depicts the regulation of ferroptosis by multiple metabolic events (such as lipogenesis, autophagy, and mitochondrial TCA cycle) and signaling pathways (such as E-cadherin-NF2-Hippo-YAP pathway, glucose-regulated AMPK signaling, and p53 and BAP1 tumor suppressor function). See text for detail. Abbreviations: TfR, transferrin receptor; PL-OOH, phospholipid hydroperoxide; PUFA-PL, phospholipid with polyunsaturated fatty acid chain; ROS, reactive oxygen species; TCA, mitochondrial TCA cycle; Gln, glutamine; Glu, glutamate; αKG, α-ketoglutarate.