Fig. 6.

Principal component analyses of M^pro protein in unbound and bound state (A) Projection of backbone atoms of M^pro protein in phase space along the first two principal eigenvectors in unbound state. (B) Projection of backbone atoms of M^pro protein in complex with lopinavir in phase space along the first two principal eigenvectors (C) Projection of backbone atoms of M^pro protein in complex with quercetin-3-rutinoside-7-glucoside in phase space along the first two principal eigenvectors (D) Superimposition of Plots of PCA analysis for M^pro protein in unbound state and bound with lopinavir and quercetin-3-rutinoside-7-glucoside. Unbound protein parameters are depicted in black color. Parameters for M^pro-lopinavir complex and M^pro-quercetin-3-rutinoside-7-glucoside complex are represented in red and green color respectively.