Fig. 6.

Morphological characteristics of cartilage tissues of DMM-induced OA mice. A, Histopathological changes on the synovium of mouse knee joint observed by HE staining after OA model establishment (400 ​× ​). B, Degree of cartilage damage of mouse knee joint assessed by safranin-O-fast green staining after OA model establishment (400 ​× ​). C, Synovitis scores of mice after OA model establishment. D, OARSI scores of mice after OA model establishment. OA mice were orally administered with normal saline, 0.1, 1, 10, or 100 ​mg/kg losartan, or intraarticularly injected with normal saline, 0.1, 1, 10 or 100 ​mg/mL losartan. ∗p ​< ​0.05 vs. sham-operated mice.