Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 24;14:138. doi: 10.1186/s12920-021-00970-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Effect of age on the expression of pattern recognition receptor genes, enrichment results of high and low TLR4 expressors, and predicted interactions with SARS-CoV-2 proteins. a Correlation matrix comparing the relationships between age, ACE2 and 21 pattern recognition receptor genes. Pearson r, P values, and Confidence intervals of r are provided in Additional file 3: Suppl Table 3a-c. Age refers to the age of the individual from which the dermal fibroblast cell line was derived. b Normalized gene counts for TLR3, TLR4, IHIF1 and ACE2 expressed as a function of age. c Enriched KEGG pathways in differentially expressed genes (absolute log2FC > 1.0 and Adjusted P Value < 0.05) between dermal fibroblast cell lines with high (> 75th percentile) and low (< 25th percentile) expression of TLR4. Based on differentially expressed genes with an absolute log2FC > 1.0 and Adjusted P Value < 0.05). d Protein–protein interactions linking differentially expressed genes between oldest (≥ 80 years) and youngest (≤ 10 years) age groups and SARS-CoV-2 proteins. SARS-CoV-2 viral proteins are represented at the center of each module, with interacting human host proteins represented with circles. Differentially expressed gene color is proportional to logFC. Physical interactions among host and viral proteins are noted as thin black lines. Four genes (ADAM9, FBLN5, FAM8A1, CLIP4) that encode proteins that interact with SARS-CoV-2 had increased expression in the oldest compared to youngest age groups (shades of red)