Figure 1.
Effect of vitamin D3 supplementation on hepatic lipid metabolism in type 2 diabetic mice. The protein levels of fatty acid synthase (FAS), sterol response element-binding protein 1c (SREBP1c), CCAAT-enhancer-binding proteins (C/EBPα), peroxisome proliferator-activated receptor (PPAR)-γ, phosphorylation of acetyl-CoA carboxylase (ACC), carnitine palmitoyltransferase 1 A (CPT1A) and PPARα in hepatic tissue from NC, DMC, and vitamin D3-treated mice (LC, 300 ng/kg of vitamin D3; HC, 600 ng/kg of vitamin D3) were analyzed by Western blot. The band level of each marker was densitometrically quantified and normalized to that of α-tubulin (cytosol) and LaminB1 (nucleus). Data were presented as fold change relative to the NC group of mean ± S.E.M for each group (n = 6). Values with the different superscript letter were significantly different (P < 0.05; ANOVA with post hoc Duncan’s multiple range test).