Table 1.
Clinicodemographic and imaging characteristics of the total population (n = 66).
| Characteristic | Control (n = 33) | MCI (n = 33) | p value |
|---|---|---|---|
| Age, years | 65.7 ± 6.4 | 65.9 ± 6.6 | 0.895 |
| Female | 22 (66.7%) | 21 (63.6%) | 0.796 |
| APOE4 carrier | 3/11 (27.2%) | 14/24 (58.3%) | 0.146 |
| Education, years | 12.3 ± 3.8 | 9.6 ± 3.7 | 0.005* |
| MMSE | 28.0 ± 1.7 | 26.1 ± 3.0 | 0.003* |
| CDR-SB | 0.364 ± 0.359 | 1.401 ± 0.879 | <0.001* |
| Vascular risk burden | 1.36 ± 1.25 | 1.70 ± 1.49 | 0.398 |
| WMH volume (×103 mm3) | 9.385 ± 11.735 | 6.862 ± 5.610 | 0.269 |
| Hippocampus volume (×103 mm3) | 3.988 ± 0.428 | 3.612 ± 0.523 | 0.002* |
| nWMH volume (×10−3) | 5.896 ± 7.007 | 4.592 ± 3.785 | 0.351 |
| nHippocampus volume (×10−3) | 1.275 ± 0.149 | 1.180 ± 0.179 | 0.030* |
| Lacunae (n) | 0.0 ± 0.0 | 0.3 ± 0.9 | 0.154 |
| Microbleeds (n) | 0.4 ± 1.7 | 1.7 ± 4.1 | 0.733 |
Note: Data are presented as the n (%) or as the mean ± standard deviation.
MMSE: Mini-mental State Examination; CDR-SB: clinical dementia rating sum of boxes; WMH: white matter hyperintensity; nWMH volume: normalized WMH volume, defined as the ratio of the WMH volume to the total intracranial volume; nHippocampus volume: normalized Hippocampus volume, defined as the ratio of the hippocampus volume to the total intracranial volume.*p < 0.05.