Table 2.
Clinical and imaging characteristics of the subgroup with known APOE4 status (n = 35).
| Characteristic | APOE4 (−) (n = 18) | APOE4 (+) (n = 17) | p value |
|---|---|---|---|
| Age, years | 65.2 ± 7.08 | 66.8 ± 6.25 | 0.494 |
| MCI | 10 (55.6%) | 14 (82.4%) | 0.088 |
| APOE alleles | 23/33 (1/17) | 34/44 (13/4) | NA |
| Female | 11 (51.1%) | 7 (41.2%) | 0.318 |
| Education, years | 12.0 ± 3.89 | 10.5 ± 4.4 | 0.288 |
| MMSE | 27.7 ± 1.9 | 26.7 ± 3.4 | 0.283 |
| CDR-SB | 0.941± 0.864 | 1.294 ± 3.445 | 0.201 |
| Vascular risk burden | 1.72 ± 1.01 | 2.18 ± 1.81 | 0.363 |
| WMH volume ( ×103 mm3) | 1.47 ± 1.00 | 1.52 ± 1.00 | 0.865 |
| Hippocampus volume (× 103 mm3) | 0.52 ± 0.79 | 0.97 ± 0.73 | 0.114 |
| nWMH volume (× 10−3) | 0.53 ± 0.80 | 1.00 ± 0.79 | 0.099 |
| nHippocampus volume (×10−3) | 0.53 ± 0.80 | 0.94 ± 0.74 | 0.122 |
| Lacunae (n) | 0.0 ± 0.0 | 0.1 ± 0.3 | 0.563 |
| Microbleeds (n) | 4.7 ± 15.0 | 1.4 ± 3.6 | 0.634 |
MMSE: Mini-mental State Examination; CDR-SB: clinical dementia rating sum of boxes; WMH: white matter hyperintensity; APOE: apolipoprotein E; nWMH: normalized total WMH volume; nHippocampus: normalized hippocampus volume; MCI: mild cognitive impairment.
Note: Data are presented as the n (%) or as the mean ± standard deviation.