Table 4.

Predictors of CDR-SB in the subgroup with a known APOE4 status (n = 35).

	Univariable regression				Multivariable regression (enter)			Multivariable regression (forward stepwise)
Independent variable	B	SE	p value	B	SE	p value	B	SE	p value
Age, years	0.004	0.004	0.347	−0.004	0.004	0.368
Education, years	−0.010	0.007	0.176	−0.014	0.006	0.032*
ApoE4	0.087	0.058	0.143	−0.062	0.058	0.295
Vascular risk burden	0.008	0.021	0.713	0.010	0.018	0.569
nWMH volume	−0.005	0.005	0.313	−0.006	0.004	0.150
nHippocampus volume	−0.455	0.151	0.005*	−0.530	0.160	0.003*	−0.445	0.137	0.003*
Ktrans of hippocampus	0.147	0.057	0.015*	0.134	0.056	0.025*	0.142	0.050	0.008*
Vp of the inferior temporal gyrus	−0.033	0.023	0.157	−0.049	0.021	0.026*
Vp of the globus pallidus	−0.022	0.033	0.521
Vp of the temporal white matter	−0.003	0.012	0.803

Note: Multiple linear regression with the forward stepwise method: R squared = 0.374, F (2, 32) = 9.559, p = 0.001.

WMH: white matter hyperintensity; nWMH: normalized total WMH volume; nHippocampus: normalized hippocampus volume; APOE: apolipoprotein E; CDR-SB: clinical dementia rating-sum of boxes. Multiple linear regression with the enter method: R squared = 0.540, F (8, 26) = 3.821, p = 0.004.*p < 0.05.