Protease inhibitor activity screening of 3 and 4.
| Protease | Compound 3a/[%] | Compound 4a/[%] |
|---|---|---|
| Cathepsin L | 7.3 ± 3.3 | 11 ± 5.0 |
| Cathepsin B | 4.9 ± 1.4 | n.i. |
| uPa | n.i. | n.i. |
| SrtA | 3.8 ± 6.4 | 2.5 ± 4.2 |
| Rhodesain | 5.7 ± 5.2 | 15 ± 4.6 |
| Cruzain | 3.6 ± 2.3 | 3.8 ± 5.4 |
| Mpro (SARS-CoV2) | n.i. | 11 ± 9 |
| PLpro (SARS-CoV) | n.i. | 11 ± 14 |
| DENV2 | n.i. | 4.8 ± 4.8 |
| ZIKV | 0.7 ± 1.2 | 17 ± 3.4 |
a
Inhibition at a compound concentration of 200 μM in DMSO as a percentage mean value ± standard deviation with n = 3. Inhibition rates below 0.5% are given as n.i. (no inhibition).