Fig. 1.

Relative mutagenicity of six whole smoke solutions (WSSs) in the mouse lymphoma assay. (A) BMDL₁₀, calculated from the exponential model of the PROAST Software using whole smoke solution as covariate approach, is the lower limit of the BMD₁₀ that is a dose that produces a predetermined change in the response of an adverse effect over control [in this case, 10% increase in mutant frequency (MF)]; NOGEL and LOGEL, determined by one way ANOVA followed by Dunnett’s test; GEF, Lowest positive response based on the global evaluation factor (GEF). A lower value indicates a higher mutagenic potential. No values were generated for NOGEL, LOGEL, and GEF in C1-HCI-20, as no positive response was observed over the tested concentrations. (B) Mutagenic potency, calculated from the slope of the linear regression of the dose–response curve.