. Author manuscript; available in PMC: 2021 May 24.

Published in final edited form as: Environ Mol Mutagen. 2017 Nov 9;59(2):103–113. doi: 10.1002/em.22151

TABLE IV.

Comparison and Rankings of the Benchmark Doses (BMDs) Producing a 10%, 50%, 100%, and 200% Increase in the Background Frequency (BMD_10–200) for the Six WSSs by PROAST

WSS ID^a	BMD₁₀ (%, v/v)		BMD₅₀ (%, v/v)		BMD₁₀₀ (%, v/v)		BMD₂₀₀ (%, v/v)
WSS ID^a	PROAST1^c	PROAST2^d	PROAST1^c	PROAST2^d	PROAST1^c	PROAST2^d	PROAST1^c	PROAST2^d
C1-ISO-60	0.051 [1]^b	0.309 [5]	0.361 [4]	0.690 [5]	0.836 [5]	0.975 [5]	1.940 [5]	1.380 [5]
C2-ISO-60	0.110 [4]	0.211 [4]	0.343 [3]	0.471 [4]	0.559 [4]	0.666 [4]	0.912 [4]	0.941 [4]
C1-HCI-20	0.404 [6]	0.326 [6]	0.724 [6]	0.728 [6]	1.130 [6]	1.030 [6]	N/A [6]	1.450 [6]
C1-HCI-60	0.069 [3]	0.059 [2]	0.146 [2]	0.131 [2]	0.201 [2]	0.185 [2]	0.277 [2]	0.262 [2]
C2-HCI-20	0.178 [5]	0.149 [3]	0.369 [5]	0.332 [3]	0.504 [3]	0.469 [3]	0.690 [3]	0.663 [3]
C2-HCI-60	0.064 [2]	0.052 [1]	0.125 [1]	0.115 [1]	0.168 [1]	0.162 [1]	0.227 [1]	0.230 [1]

Sixty (or 20) of Cigarette #1 (or #2) were smoked under ISO (or HCI) regimen (more information in Table I).

Number in square bracket indicates the potency ranking of the WSSs.

PROAST1, BMDs calculated from exponential model of the PROAST Software for the MLA MF data.

PROAST2, BMDs calculated from exponential model of the PROAST Software for the MLA MF data using whole smoke solution as a covariate.