Table 2.
Means (SEM) for WT and Pink1−/− rats in each of the three testing conditions (baseline, hypoxia, MCS) over time.
| Ventilation variable and condition | WT Mean (SEM) |
Pinkl−/− Mean (SEM) |
||||||
|---|---|---|---|---|---|---|---|---|
| 4 mo | 6 mo | 8 mo | 10 mo | 4 mo | 6 mo | 8 mo | 10mo | |
| Baseline | ||||||||
| Frequency ** | 124.66 (4.79) | 118.44 (4.52) | 110.55 (3.14) | 117.38 (5.69) | 138.83 (3.77) | 137.28 (4.077) | 131.95 (4.87) | 133.80 (3.17) |
| Tidal volume (VT/100g) * | 0.230 (0.02) | 0.24 (0.014) | 0.23 (0.01) | 0.22 (0.02) | 0.27 (0.009) | 0.20 (0.02) | 0.18 (0.01) | 0.21 (0.014) |
| Minute ventilation (VE/100g) | 35.45 (1.44) | 27.09 (0.96) | 23.49 (0.88) | 25.06 (0.85) | 36.73 (1.43) | 27.092 (0.96) | 22.59 (1.12) | 26.47 (1.30) |
| Mean inspiratory flow (VT/TI/100g) | 1.40(0.06) | 1.04(0.04) | 0.90 (0.04) | 0.95 (0.03) | 1.50 (0.05) | 1.049 (0.05) | 0.897 (0.05) | 1.07 (0.05) |
| Peak inspiratory flow (PIF) | 0.81 (0.27) | 0.81 (0.03) | 0.75 (0.03) | 0.86 (0.04) | 0.85 (0.03) | 0.86 (0.05) | 0.79 (0.04) | 0.96 (0.05) |
| Peak expiratory flow (PEF) | 0.63 (0.02) | 0.66 (0.03) | 0.63 (0.02) | 0.75 (0.04) | 0.61 (0.02) | 0.66 (0.04) | 0.62 (0.04) | 0.75 (0.04) |
| Hypoxia | ||||||||
| Frequency | 170.76(11.17) | 169.12(9.32) | 166.83 (9.67) | 160.47 (8.66) | 161.95 (5.61) | 164.22 (5.86) | 154.40(6.71) | 151.87 (5.45) |
| Tidal volume (VT/100 g) | 0.29 (0.02) | 0.22 (0.015) | 0.19 (0.02) | 0.22 (0.03) | 0.34 (0.02) | 0.22 (0.0096) | 0.21 (0.014) | 0.24 (0.013) |
| Minute ventilation (VE/100g) | 47.09 (2.29) | 35.97 (1.06) | 30.58 (1.53) | 32.51 (2.05) | 53.66 (2.72) | 35.97 (1.06) | 31.02(1.78) | 35.64 (1.48) |
| Mean inspiratory flow (VT/TI/100g) | 1.60(0.07) | 1.20(0.04) | 1.02 (0.05) | 1.11 (0.08) | 1.83 (0.074) | 1.17(0.035) | 1.09 (0.054) | 1.26 (0.06) |
| Peak inspiratory flow (PIF) | 0.89 (0.05) | 0.87 (0.05) | 0.78 (0.04) | 0.95 (0.05) | 1.00(0.035) | 0.90 (0.045) | 0.90 (0.06) | 1.10(0.05) |
| Peak expiratory flow (PEF) | 0.92 (0.05) | 0.93 (0.03) | 0.86 (0.04) | 0.99 (0.06) | 1.01 (0.57) | 0.91 (0.05) | 0.88 (0.07) | 1.04 (0.06) |
| MCS | ||||||||
| Frequency *** | 168.11 (3.26) | 165.77 (3.17) | 168.61 (5.01) | 162.96 (2.64) | 178.58 (4.65) | 164.14 (4.52) | 161.38 (4.40) | 157.61 (3.67) |
| Tidal volume (VT/100 g) | 0.52 (0.027) | 0.37 (0.0092) | 0.36 (0.023) | 0.36 (0.02) | 0.513 (0.022) | 0.34 (0.01) | 0.33 (0.02) | 0.40 (0.03) |
| Minute ventilation (/100g) | 86.58 (4.86) | 61.01 (2.21) | 58.78 (3.71) | 58.77 (3.02) | 91.03 (3.94) | 61.005 (2.21) | 51.96(3.02) | 61.91 (3.93) |
| Mean inspiratory flow (VT/TI/100g) | 3.002(0.17) | 2.12(0.07) | 2.06(0.13) | 2.07(0.12) | 3.18 (0.13) | 1.92(0.064) | 1.82(0.10) | 2.18 (0.14) |
| Peak inspiratory flow (PIF) | 1.40(0.086) | 1.37(0.07) | 1.36 (0.08) | 1.54(0.08) | 1.46 (0.043) | 1.27 (0.06) | 1.34(0.08) | 1.56 (0.05) |
| Peak expiratory flow (PEF) | 1.23 (0.07) | 1.21 (0.06) | 1.20 (0.06) | 1.33 (0.07) | 1.22 (0.04) | 1.08 (0.06) | 1.16(0.07) | 1.31 (0.06) |
Statistical significance within variables is indicated by asterisk (*p < 0.05, **p<0.01, ***p< 0.001)