Table 4.
Linear regression analysis of log-transformed serum sodium levels and quintiles of cognitive test scores by hyponatremia and hypernatremia status
| n | Unadjusted model | Adjusted modela | |||
|---|---|---|---|---|---|
| Beta ± SE | P | Beta ± SE | P | ||
| CEARD WLT-IR | |||||
| Normal | 2446 | 1 | 1 | ||
| Hyponatremia | 87 | -0.58 ± 0.18 | 0.002 | -0.34 ± 0.15 | 0.035 |
| Hypernatremia | 8 | 0.39 ± 0.67 | 0.565 | 0.13 ± 0.68 | 0.852 |
| CEARD WLT-DR | |||||
| Normal | 2445 | 1 | 1 | ||
| Hyponatremia | 87 | -0.69 ± 0.15 | <0.001 | -0.48 ± 0.10 | <0.001 |
| Hypernatremia | 8 | 0.60 ± 0.59 | 0.318 | 0.42 ± 0.62 | 0.496 |
| AFT | |||||
| Normal | 2428 | 1 | 1 | ||
| Hyponatremia | 86 | -0.62 ± 0.19 | 0.002 | -0.38 ± 0.19 | 0.052 |
| Hypernatremia | 9 | -0.63 ± 0.65 | 0.334 | -0.69 ± 0.44 | 0.127 |
| DSST | |||||
| Normal | 2376 | Reference | Reference | ||
| Hyponatremia | 81 | -0.52 ± 0.23 | 0.030 | -0.18 ± 0.21 | 0.382 |
| Hypernatremia | 8 | 0.23 ± 0.47 | 0.620 | 0.07 ± 0.41 | 0.866 |
aAdjusted for sex, age, marital status, ethnicity, smoking status, alcohol consumption, physical activity, income, obesity, education, GFR, serum glucose levels, diuretics use, diabetes, CVD, stroke, COPD, thyroid disease, and liver disease