Table 2.
Functional outcome of bilateral RCC cohort regardless of time interval between tumors
| Variables | PN ➔ PN (N = 48) | PN ➔ RN (N = 8) |
RN ➔ PN (N = 25) |
P value § |
|---|---|---|---|---|
| Preoperative eGFR, ml/min/1.73 m2, mean (SD) (before 1st surgery) | 84.7 ± 25.4 | 83.1 ± 19.6 | 79.6 ± 33.4 | 0.759 |
| Latest eGFR, ml/min/1.73 m2, mean (SD) | 79.4 ± 33.9 | 41.4 ± 28.3 | 61.2 ± 29.8 | 0.003 |
| p = 0.108 a | ||||
| eGFR decline from baseline, mean (SD) | ||||
| Postoperative 1 week (after 2nd surgery) | 6.9 ± 18.5 | 28.5 ± 18.2 | 10.6 ± 16.5 | 0.009 |
| p = 0.031 a | ||||
| Postoperative 1 month (after 2nd surgery) | 5.1 ± 15.0 | 28.7 ± 23.2 | 9.9 ± 13.2 | 0.001 |
| p = 0.058 a | ||||
| Postoperative 1 year (after 2nd surgery) | 5.8 ± 17.5 | 29.4 ± 24.2 | 31.3 ± 6.3 | 0.018 |
| p = 0.035 a | ||||
| Latest | −0.64 ± 22.5 | 30.5 ± 26.6 | −2.7 ± 21.3 | 0.001 |
| p = 0.001 a | ||||
| De novo CKD, stage≥3 | ||||
| Baseline CKD, before 1st surgery | 8 (16.7%) | 1 (12.5%) | 5 (20.0%) | 0.874 |
| Baseline CKD, before 2nd surgery | 6 (12.5%) | 1 (12.5%) | 9 (36.0%) | 0.049 |
| De novo, ≤ 1 year after 2nd surgery | 9 (18.8%) | 4 (50%) | 5 (20%) | 0.036 |
| De novo, > 1 year after 2nd surgery | 0 (0%) | 2 (25.0%) | 1 (4.0%) | < 0.001 |
| Total number of CKD patients last follow-up | 15 (31.3%) | 7 (87.5%) | 15 (60%) | < 0.001 |
SD Standard Deviation
eGFR follow-up duration (mean ± SD): 65.6 ± 47.6 months (range, 0–166 months)
8 patients with RN followed by RN were excluded from the analysis
§ Evaluates differences among all surgery groups at specific points
a Evaluates differences between ‘PN → RN’ group and ‘RN → PN’ group