Table 6.
Multivariate Cox regression analyses of variables associated with de novo CKD during the entire follow-up period
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) | 1.031 | 1.009–1.053 | 0.005 | 1.005 | 0.971–1.040 | 0.780 |
| BMI | 1.029 | 0.946–1.120 | 0.500 | |||
| Sex, male | 0.607 | 0.306–1.205 | 0.154 | |||
| DM | 1.530 | 0.806–2.905 | 0.194 | |||
| HTN | 1.956 | 1.147–3.335 | 0.014 | 1.905 | 1.172–3.265 | 0.010 |
| Baseline eGFR | 0.992 | 0.982–1.002 | 0.106 | |||
| Baseline Hb | 1.002 | 0.902–1.114 | 0.969 | |||
| EBL (1st surgery) | 1.000 | 0.999–1.000 | 0.784 | |||
| EBL (2nd surgery) | 1.000 | 0.999–1.001 | 0.680 | |||
| Ischemic time (1st surgery) | 1.001 | 0.972–1.032 | 0.921 | |||
| Ischemic time (2nd surgery) | 0.985 | 0.956–1.014 | 0.301 | |||
| Pathologic tumor size (1st surgery) | 1.016 | 1.007–1.025 | 0.001 | 1.013 | 1.000–1.027 | 0.051 |
| Pathologic tumor size (2nd surgery) | 1.004 | 0.997–1.011 | 0.278 | |||
| Time between operations | 1.000 | 1.000–1.001 | 0.056 | |||
| Surgery sequence | ||||||
| PN ➔ PN | Reference | Reference | ||||
| PN ➔ RN | 2.919 | 1.386–6.146 | 0.001 | 1.888 | 1.088–4.055 | < 0.001 |
| RN ➔ PN | 2.190 | 1.165–4.114 | 0.015 | 1.041 | 1.003–3.258 | 0.103 |
| PN (unilateral case) | 0.782 | 0.366–1.669 | 0.525 | 0.233 | 0.088–0.614 | 0.718 |
| Tumor chronology | ||||||
| Synchronous | Reference | Reference | ||||
| Metachronous | 2.250 | 1.121–4.516 | 0.023 | 2.682 | 1.032–6.973 | 0.043 |
| Tumor multiplicity | ||||||
| Unilateral | Reference | |||||
| Bilateral | 1.421 | 0.824–2.449 | 0.206 | |||