Table 3.
Reclassification Statistics (95% CI) for post-stroke cognitive impairment by plasma sST2 Among Participants
| C statistic | Calibration statistic | NRI (Continuous) | IDI | |||||
|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) | p value | χ2 | p value | Estimate (95% CI), % | p value | Estimate (95% CI), % | p value | |
| Cognitive impairment: MoCA | ||||||||
| Conventional model | 0.678 (0.640 to 0.715) | 6.12 | 0.63 | Reference | Reference | |||
| Conventional model + sST2 (quartiles) | 0.691 (0.653 to 0.727) | 0.07 | 11.10 | 0.20 | 18.5 (3.0 to 33.9) | < 0.01 | 1.6 (0.6 to 2.6) | < 0.01 |
| Cognitive impairment: MMSE | ||||||||
| Conventional model | 0.672 (0.633 to 0.708) | 1.42 | 0.99 | Reference | Reference | |||
| Conventional model + sST2 (quartiles) | 0.683 (0.644 to 0.719) | 0.11 | 5.19 | 0.74 | 17.8 (2.1 to 33.4) | < 0.01 | 1.0 (0.2 to 1.8) | < 0.01 |
MoCA score of < 23 or MMSE score of < 27 indicates cognitive impairment
Conventional model included age, sex, education level, systolic blood pressure, baseline National Institutes of Health Stroke Scale score, baseline modified Rankin Scale score, hypertension, diabetes mellitus, ischemic stroke subtype, hsCRP, anticoagulant treatment and hypoglycemic treatment
Abbreviations: sST2 soluble suppression of tumorigenicity 2, CI confidence interval, IDI integrated discrimination index, MoCA Montreal Cognitive Assessment, NRI net reclassification improvement