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. 2020 May 29;11:1178122X20913274. doi: 10.1177/1178122X20913274

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Schematic diagram of HSV-1 genomes. (A) WT HSV-1 has unique sequences flanked by repeated sequences. (B) T-VEC lacks the gene that encodes ICP34.5 and replaces ICP34.5 with the gene that expresses human GM-CSF. (C) The HF10 genome has partial or completely inverted duplication of UL52-UL56 genes replacing a 2295-bp segment in the TRL region. In addition, UL43, UL49.5, and UL55 genes are not expressed due to frame-shift mutations caused by deletion of UL56 and LATs at the UL56-IRL junction. GM-CSF indicates granulocyte-macrophage colony-stimulating factor; IRL, internal repeat long; IRS, internal repeat short; LATs, latency-associated transcripts; TRL, terminal repeat long; TRS, terminal repeat short; T-VEC, Talimogene Laherparepvec; UL, unique long; US, unique short; WT HSV, wild-type herpes simplex virus.