Table 1.
Characteristics of patients
| DMG | Placebo | |||
|---|---|---|---|---|
| Baseline (n = 20) | 12 months (n = 17) | Baseline (n = 10) | 12 months (n = 9) | |
| Age (years) | 54.9 ± 5.7 | 52.1 ± 5.9 | ||
| Sex (M/F) | 6/14 | 1/9 | ||
| SPMS (M/F) | 4/10 | 0/8 | ||
| PPMS (M/F) | 2/4 | 1/1 | ||
| Weight (kg) | 75.8 ± 16.3 | 75.6 ± 21.3 | ||
| Height (cm) | 167.6 ± 10.1 | 166.4 ± 7.1 | ||
| Disease duration (years) | 13.8 ± 9.3 | 18.8 ± 10.0 | ||
| Study variables | ||||
| EDSS (score) | 4.6 ± 2.0 (5.3) | 4.5 ± 2.0 (4.5) | 5.2 ± 1.5 (6.0) | 5.3 ± 1.7 (6.0) |
| FIS-D (score) | 85.8 ± 26.8 (86.5) | 76.0 ± 35.0 (86.0) | 73.3 ± 25.7 (73.5) | 81.6 ± 21.5 (89.0) |
| PASAT (score) | 40.6 ± 8.8 (39.0) | 41.4 ± 12.0 (36.0) | 35.6 ± 7.0 (34.0) | 44.2 ± 9.7 (42.0) |
| Gait velocity (km/h) | 2.5 ± 1.1 | 2.5 ± 1.2 | 2.6 ± 0.7 | 2.6 ± 0.8 |
| Stride length (m) | 0.50 ± 0.1 | 0.52 ± 0.2 | 0.49 ± 0.1 | 0.55 ± 0.2 |
| Stride variability (%) | 4.2 ± 2.7 | 4.4 ± 4.5 | 12.9 ± 22.9 | 11.7 ± 17.1 |
| 6 min Walking Test (m) | 259.9 ± 141.8 | 267.2 ± 135.6 | 268.6 ± 80.5 | 277.3 ± 84.5 |
| Knee angle stance (left/2 + right/2)(°) | 16.3 ± 4.9 | 16.4 ± 4.4 | 17.8 ± 7.5 | 17.5 ± 6.1 |
| Knee angle swing (left/2 + right/2)(°) | 48.8 ± 10.5 | 49.1 ± 9.2 | 47.8 ± 7.7 | 49.7 ± 6.7 |
SPMS secondary progressive MS, PPMS primary progressive MS, EDSS Expanded Disability Status Scale, FIS-D Fatigue Impact Scale, PASAT Paced Auditory Serial Addition Test, mean ± sd () = median