Table 2.

Comedications at baseline of patients exposed to Nervous System drugs

N, %	Total N = 137,880	Cases N = 12,616	Controls N = 125,264	p-value
Acetic acid derivatives	58,208, 42.2	5652, 44.8	52,556, 42.0	< 0.001
Analgesics (metamizol and paracetamol)	109,801, 79.6	10,771, 85.4	99,030, 79.1	< 0.001
Anti-dementia agents	8907, 6.5	861, 6.8	8046, 6.4	0.080
Antidepressants	39,851, 28.9	4465, 35.4	35,386, 28.2	< 0.001
Antihypertensive agents	3774, 2.7	576, 4.6	3198, 2.6	< 0.001
Antithrombotic drugs	39,951, 29.0	8613, 68.3	31,338, 25.0	< 0.001
Antipsychotics	20,024, 14.5	2361, 18.7	17,663, 14.1	< 0.001
Anxiolytics	62,234, 45.1	6536, 51.8	55,698, 44.5	< 0.001
Beta-blockers	18,022, 13.1	2864, 22.7	15,158, 12.1	< 0.001
Blood glucose-lowering drugs	20,733, 15.0	2896, 23.0	17,837, 14.2	< 0.001
Calcium channel-blockers	18,013, 13.1	2448, 19.4	15,565, 12.4	< 0.001
Cardiac therapy	13,233, 9.6	2251, 17.8	10,982, 8.8	< 0.001
Coxibs and oxicams	22,471, 16.3	2020, 16.0	20,451, 16.3	0.369
Diuretics	28,656, 20.8	3794, 30.1	24,862, 19.8	< 0.001
Gastrointestinal tract	2505, 1.8	491, 3.9	2014, 1.6	< 0.001
Hypnotics and sedatives	23,208, 16.8	2607, 20.7	20,601, 16.4	< 0.001
Insulins	6072, 4.4	1276, 10.1	4796, 3.8	< 0.001
Lipid-modifying agents	42,897, 31.1	6119, 48.5	36,778, 29.4	< 0.001
Opioids (phentanil, buprenorphine and tramadol)	33,489, 24.3	3672, 29.1	29,817, 23.8	< 0.001
Propionic acid derivatives	93,012, 67.5	8839, 70.1	84,173, 67.2	< 0.001
Psychostimulants, ADHD-agents and nootropics	11,948, 8.7	1390, 11.0	10,558, 8.4	< 0.001
Renin-angiotensin agents	54,778, 39.7	6657, 52.8	48,121, 38.4	< 0.001
Other anti-inflammatories (glucosamine and chondroitin sulphate)	17,342, 12.6	1433, 11.4	15,909, 12.7	< 0.001

ADHD attention deficit hyperactivity disorder