Table 4.

Univariate and Stepwise Multivariate Linear Regression of Percent ΔAOD500 With the General and Ocular Parameters

	Univariate Analysis		Stepwise Multivariate Analysis
Parameters	Coefficient (95% CI)	P Value	Coefficient (95% CI)	P Value
Demographic parameters
Age, per 1-year increase	−2.58 (−2.89 to −2.26)	<0.001	−2.11 (−2.59 to −1.64)	<0.001
Sex, male versus female	5.07 (−1.45 to 11.59)	0.127
Systemic hypertension, yes versus no	−10.25 (−18.14 to −2.37)	0.011
Diabetes mellitus, yes versus no	−5.56 (−12.86 to 1.73)	0.135
Ocular parameters before pupil dilation
Presence of high myopia (AL > 26.0 mm)	21.90 (12.35 to 31.45)	<0.001	15.35 (3.63 to 27.07)	0.010
Anterior chamber depth, per 1-mm increase	4.69 (−3.50 to 12.88)	0.261
Lens thickness, per 1-mm increase	−41.89 (−50.46 to −33.32)	<0.001
Corneal diameter, per 1-mm increase	8.81 (0.74 to 16.87)	0.032
Flat meridian (K1), per 1-D increase	−1.68 (−3.77 to 0.41)	0.115
Flat meridian (K2), per 1-D increase	−1.34 (−3.35 to 0.66)	0.189
TISA500, per 1-mm2 increase	66.02 (23.76 to 108.29)	0.002	60.78 (8.85 to 112.82)	0.022
LV, per 1-mm increase	−4.31 (−14.21 to 5.58)	0.393
ACW, per 1-mm increase	0.47 (−6.97 to 7.92)	0.901
ATA, per 1-mm increase	13.95 (8.14 to 19.76)	<0.001	11.21 (4.53 to 17.89)	0.001
Average nuclear density, per 1-unit increase	−0.38 (−1.92 to 1.16)	0.627
Maximum nuclear density, per 1-unit increase	0.10 (−0.29 to 0.49)	0.616
Ocular changes after mydriasis
ΔIOP, per 1-mm Hg increase	−0.16 (−1.88 to 1.55)	0.853
ΔPupil diameter, per 1-mm increase	−3.60 (−7.88 to 0.69)	0.100

Δ = anterior segment changes after dilation (mydriasis minus baseline); IOP = intraocular pressure; AOD = angle open distance; TISA = trabecular-iris space area; LV = lens vault; ACW = anterior chamber width; ATA = angle to angle width.

Bold indicates statistical significance.