Table 1.
Dose-Response Values Corresponding to Different Concentrations of Eight Tested Substances and Their Effect on % of Mortality Rate ± SEM in ARPE-19 e BALB3T3 Cell Lines
Mortality Rate ± SEM (%) | |||
---|---|---|---|
Tested Substance, Molecular Formula, (Purity (%), CAS Number) | Tested Concentrations (ppm) | % ARPE-19 Cells | BALB3T3 Cells |
p-Xylene, anhydrous, C8H10, (99.8%, CAS 106-42-3) | 1.71 | 98 ± 1 | 99 ± 1 |
1.55 | 70 ± 2 | 75 ± 2 | |
1.07 | 8 ± 2 | 11 ± 1 | |
Ethylbenzene, anhydrous, C8H10, (99.87%, CAS 100-41-4) | 8.50 | 98 ± 1 | 99 ± 1 |
7.63 | 78 ± 1 | 77 ± 1 | |
0.05 | 22 ± 6 | 14 ± 6 | |
Perfluorooctanoic acid, C8HF15O2 (PFOA, 98.8%, CAS 335-67-1) | 568 | 87 ± 1 | 96 ± 1 |
284 | 71 ± 1 | 67 ± 3 | |
142 | 58 ± 1 | 52 ± 2 | |
56.80 | 43 ± 1 | 36 ± 1 | |
28.40 | 38 ± 2 | 25 ± 2 | |
5.68 | 12 ± 2 | 13 ± 2 | |
2.84 | 9 ± 3 | 5 ± 1 | |
1H,1H,7H-dodecafluoro-1-heptanol, C7H4F12O (DFH, 98%, CAS 335-99-9) | 18,375 | 99 ± 1 | 97 ± 1 |
9800 | 96 ± 1 | 97 ± 1 | |
9114 | 99 ± 1 | 97 ± 1 | |
980 | 28 ± 2 | 8 ± 1 | |
98 | 20 ± 1 | 7 ± 1 | |
49 | 20 ± 1 | 5 ± 1 | |
24.50 | 16 ± 1 | 5 ± 1 | |
12.25 | 15 ± 1 | 3 ± 1 | |
6.13 | 13 ± 1 | 2 ± 1 | |
3.06 | 9 ± 2. | 2 ± 1 | |
Hexafluoro-1,2,3,4-tetrachlorobutane, C4Cl4F6 (90%, CAS 375-45-1 | 90,000 | 90 ± 2 | 84 ± 3 |
45,000 | 52 ± 3 | 44 ± 2 | |
22,500 | 37 ± 2 | 31 ± 1 | |
9000 | 17 ± 1 | 16 ± 1 | |
900 | 12 ± 1 | 10 ± 1 | |
450 | 9 ± 1 | 6 ± 1 | |
225 | 9 ± 1 | 6 ± 1 | |
112.5 | 5 ± 2 | 3 ± 1 | |
1H-perfluoroctane, CF3(CF2)7H (1H-PFO, 98.4%, CAS 335-65-9) | 984,000 | 98 ± 1 | 94 ± 2 |
492,000 | ND | 97 ± 2 | |
246,000 | 60 ± 1 | 78 ± 2 | |
123,000 | 44 ± 1 | 48 ± 2 | |
61,500 | 28 ± 2 | 21 ± 1 | |
30,750 | 17 ± 2 | 9 ± 1 | |
15,350 | 7 ± 2 | 1 ± 1 | |
1H,1H,1H,2H,2H-perfluorooctane, C8H5F13 (5H-PFO, 97%, CAS 80793-17-5) | 970,000 | 26 ± 2 | 13 ± 1 |
485,000 | 24 ± 1 | 12 ± 1 | |
242,500 | 16 ± 1 | 8 ± 1 | |
121,250 | 11 ± 2 | 5 ± 1 | |
60,625 | 8 ± 2 | 6 ± 1 | |
30,312 | 8 ± 2 | 5 ± 1 | |
15,156 | 4 ± 2 | 5 ± 1 | |
7578 | 2 ± 2 | 3 ± 1 | |
3789 | −3 ± 2 | 4 ± 1 | |
1894 | −6 ± 1 | 4 ± 1 | |
Perfluoro-2-butyltetrahydrofuran, C8F16O (99.71%, CAS 335-36-4) | 997,100 | 12 ± 1 | 5 ± 1 |
498,550 | 12 ± 1 | 5 ± 1 | |
249,275 | 11 ± 1 | 3 ± 1 | |
124,637 | 9 ± 2 | 0 ± 1 | |
62,318 | 6 ± 1 | 3 ± 1 | |
31,159 | −1 ± 1 | 4 ± 1 |
In bold: Minimal concentration (ppm) resulting in cytotoxicity in at least one cell line.
ND, not determined.