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. 2021 May 19;10(6):24. doi: 10.1167/tvst.10.6.24

Table 1.

Dose-Response Values Corresponding to Different Concentrations of Eight Tested Substances and Their Effect on % of Mortality Rate ± SEM in ARPE-19 e BALB3T3 Cell Lines

Mortality Rate ± SEM (%)
Tested Substance, Molecular Formula, (Purity (%), CAS Number) Tested Concentrations (ppm) % ARPE-19 Cells BALB3T3 Cells
p-Xylene, anhydrous, C8H10, (99.8%, CAS 106-42-3) 1.71 98 ± 1 99 ± 1
1.55 70 ± 2 75 ± 2
1.07 8 ± 2 11 ± 1
Ethylbenzene, anhydrous, C8H10, (99.87%, CAS 100-41-4) 8.50 98 ± 1 99 ± 1
7.63 78 ± 1 77 ± 1
0.05 22 ± 6 14 ± 6
Perfluorooctanoic acid, C8HF15O2 (PFOA, 98.8%, CAS 335-67-1) 568 87 ± 1 96 ± 1
284 71 ± 1 67 ± 3
142 58 ± 1 52 ± 2
56.80 43 ± 1 36 ± 1
28.40 38 ± 2 25 ± 2
5.68 12 ± 2 13 ± 2
2.84 9 ± 3 5 ± 1
1H,1H,7H-dodecafluoro-1-heptanol, C7H4F12O (DFH, 98%, CAS 335-99-9) 18,375 99 ± 1 97 ± 1
9800 96 ± 1 97 ± 1
9114 99 ± 1 97 ± 1
980 28 ± 2 8 ± 1
98 20 ± 1 7 ± 1
49 20 ± 1 5 ± 1
24.50 16 ± 1 5 ± 1
12.25 15 ± 1 3 ± 1
6.13 13 ± 1 2 ± 1
3.06 9 ± 2. 2 ± 1
Hexafluoro-1,2,3,4-tetrachlorobutane, C4Cl4F6 (90%, CAS 375-45-1 90,000 90 ± 2 84 ± 3
45,000 52 ± 3 44 ± 2
22,500 37 ± 2 31 ± 1
9000 17 ± 1 16 ± 1
900 12 ± 1 10 ± 1
450 9 ± 1 6 ± 1
225 9 ± 1 6 ± 1
112.5 5 ± 2 3 ± 1
1H-perfluoroctane, CF3(CF2)7H (1H-PFO, 98.4%, CAS 335-65-9) 984,000 98 ± 1 94 ± 2
492,000 ND 97 ± 2
246,000 60 ± 1 78 ± 2
123,000 44 ± 1 48 ± 2
61,500 28 ± 2 21 ± 1
30,750 17 ± 2 9 ± 1
15,350 7 ± 2 1 ± 1
1H,1H,1H,2H,2H-perfluorooctane, C8H5F13 (5H-PFO, 97%, CAS 80793-17-5) 970,000 26 ± 2 13 ± 1
485,000 24 ± 1 12 ± 1
242,500 16 ± 1 8 ± 1
121,250 11 ± 2 5 ± 1
60,625 8 ± 2 6 ± 1
30,312 8 ± 2 5 ± 1
15,156 4 ± 2 5 ± 1
7578 2 ± 2 3 ± 1
3789 −3 ± 2 4 ± 1
1894 −6 ± 1 4 ± 1
Perfluoro-2-butyltetrahydrofuran, C8F16O (99.71%, CAS 335-36-4) 997,100 12 ± 1 5 ± 1
498,550 12 ± 1 5 ± 1
249,275 11 ± 1 3 ± 1
124,637 9 ± 2 0 ± 1
62,318 6 ± 1 3 ± 1
31,159 −1 ± 1 4 ± 1

In bold: Minimal concentration (ppm) resulting in cytotoxicity in at least one cell line.

ND, not determined.