TABLE 2.
Subjective effects of initial opioid misuse endorsement by non-OUD and OUD individuals in pilot and replication samples
| Pilot (N = 29) |
Replication (N = 50) |
||||||
|---|---|---|---|---|---|---|---|
| Endorsement (%) |
Endorsement(%) |
||||||
| Subjective response item | ARCI scale(s) | Non-OUD | OUD | p Value | Non-OUD | OUD | p Value |
| My speech was slurred | P | 57.1 | 73.3 | 0.60 | 4.0 | 52.0 | 0.0005 |
| I had a feeling of just dragging along rather than coasting | P | 57.1 | 53.3 | 1.00 | 28.0 | 52.0 | 0.15 |
| I felt like avoiding people although I usually did not feel this way | P | 28.6 | 73.3 | 0.04 | 8.0 | 40.0 | 0.02 |
| It seemed harder than usual to move around | P | 64.3 | 60.0 | 1.00 | 36.0 | 56.0 | 0.26 |
| I was moody | P | 7.1 | 80.0 | 0.0004 | 4.0 | 64.0 | <0.0001 |
| People might have said that I was a little dull | P, B* | 57.1 | 66.7 | 0.88 | 24.0 | 36.0 | 0.54 |
| I felt dizzy | P | 42.9 | 40.0 | 1.00 | 40.0 | 48.0 | 0.78 |
| Things around me seemed more pleasing than usual | M | 64.3 | 86.7 | 0.33 | 44.0 | 68.0 | 0.15 |
| I felt drowsy | P, L* | 78.6 | 80.0 | 1.00 | 68.0 | 88.0 | 0.17 |
| I feared I would lose the contentment I had then | M | 14.3 | 60.0 | 0.03 | 20.0 | 56.0 | 0.02 |
| I felt in complete harmony with the world and those about me | M | 28.6 | 66.7 | 0.09 | 32.0 | 76.0 | 0.005 |
| I could completely appreciate what others were saying when I was in that mood | M | 35.7 | 46.7 | 0.82 | 36.0 | 62.5 | 0.12 |
| I would be happy all the time if I felt us I felt then | M | 28.6 | 93.3 | 0.001 | 12.0 | 64.0 | 0.0005 |
| I felt so good that I knew other people could tell it | M | 42.9 | 66.7 | 0.36 | 32.0 | 68.0 | 0.02 |
| I felt as if something pleasant just happened to me | M | 78.6 | 73.3 | 1.00 | 40.0 | 80.0 | 0.009 |
| I felt as if I would be more popular with people | A, M | 21.4 | 73.3 | 0.02 | 20.0 | 60.0 | 0.009 |
| I felt a very pleasant emptiness | A, M | 42.9 | 53.3 | 0.85 | 16.0 | 48.0 | 0.03 |
| My thoughts came more easily than usual | A, M, B | 21.4 | 46.7 | 0.30 | 16.0 | 60.0 | 0.004 |
| I felt less discouraged than usual | A, M | 28.6 | 73.3 | 0.04 | 40.0 | 76.0 | 0.02 |
| I felt more excited than dreamy | P*, A | 7.1 | 46.7 | 0.004 | 24.0 | 48.0 | 0.14 |
| My memory seemed sharper to me than usual | A, B | 7.1 | 46.7 | 0.05 | 12.0 | 36.0 | 0.10 |
| I felt as if I could write for hours | A, B | 7.1 | 26.7 | 0.37 | 8.0 | 32.0 | 0.08 |
| Some of my body parts were tingling | A, L, B | 50.0 | 60.0 | 0.87 | 8.0 | 68.0 | 0.0006 |
| I felt itchy | – | 7.1 | 93.3 | <0.0001 | 12.0 | 72.0 | <0.0001 |
| My movements seemed faster than usual | B | 0 | 40.0 | 0.03 | 8.0 | 40.0 | 0.02 |
| My hands felt clumsy | L | 50.0 | 46.7 | 1.00 | 8.0 | 33.3 | 0.06 |
| I noticed my hand shook when I tried to write | L | 7.1 | 20.0 | 0.64 | 0.0 | 16.7 | 0.11 |
| I had a disturbance in my stomach | L | 14.3 | 53.3 | 0.07 | 28.0 | 44.0 | 0.38 |
| I felt anxious and upset | L | 7.1 | 40.0 | 0.10 | 20.0 | 32.0 | 0.52 |
| I had unusual weakness of my muscles | L | 64.3 | 46.7 | 0.56 | 16.0 | 45.8 | 0.05 |
| A thrill had gone through me one or more times | P*, L | 42.9 | 66.7 | 0.36 | 24.0 | 56.0 | 0.04 |
| My movements were free, relaxed, and pleasurable | L* | 71.4 | 93.3 | 0.28 | 40.0 | 96.0 | <0.0001 |
| I did not like the way the drug made me feel | – | 28.6 | 20.0 | 0.92 | 44.0 | 28.0 | 0.38 |
| I was not as active as usual | P | – | – | – | 60.0 | 64.0 | 1.00 |
| I felt sluggish | P | – | – | – | 48.0 | 52.0 | 1.00 |
| My head felt heavy | P | – | – | – | 28.0 | 48.0 | 0.24 |
| I was full of energy | P* | – | – | – | 12.0 | 48.0 | 0.01 |
| I said things in the easiest possible way | M | – | – | – | 56.0 | 65.2 | 0.72 |
| I had a pleasant feeling in my stomach | M | – | – | – | 28.0 | 48.0 | 0.24 |
| I felt more clearheaded than dreamy | P*, M, B | – | – | – | 16.0 | 50.0 | 0.03 |
| I was in the mood to talk about the feelings I had | M, B | – | – | – | 32.0 | 52.0 | 0.25 |
| I felt very patient | A, L* | – | – | – | 52.0 | 56.0 | 1.00 |
| I had a weird feeling | A, L | – | – | – | 52.0 | 72.0 | 0.24 |
| I had better control over myself than usual | B | – | – | – | 12.0 | 48.0 | 0.01 |
| My movements seemed slower than ritual | B* | – | – | – | 44.0 | 52.0 | 0.78 |
| I found it hard to keep my mind on a task or job | B* | – | – | – | 32.0 | 56.0 | 0.15 |
| I didn’t feel like reading anything then | B* | – | – | – | 48.0 | 68.0 | 0.25 |
| I felt an increasing awareness of bodily sensations | L | – | – | – | 24.0 | 58.3 | 0.03 |
*
Reverse coded in scale
P = Pentobarbital chlorpromazine alcohol group; A = Amphetamine group; M = Morphine Benzedrine group; L = Lysergic acid diethylamide group; B = Benzedrine group; Chi-square tests (continuity-adjusted) were performed.