Table 1:
Treatment | Animal’s Treated | 4 hr Post-treatment Mortality (n) | 24 hr Post-treatment Mortality (n) | Seizure Termination (n) |
---|---|---|---|---|
MDZ + PEG200 | 19 | 1 (5%) | 0 | N.E. |
MDZ + 2 mg/kg Retigabine | 16 | 0 | 0 | N.E. |
MDZ + 15 mg/kg Retigabine | 21 | 1 (5%) | 1 (5%) | N.E. |
MDZ alone | 18 | 0 | 0 | N.E. |
15 mg/kg Retigabine | 19 | 1 (5%) | 0 | N.E. |
30 mg/kg Retigabine | 7 | 4 (57%) | 3 (43%) | N.E. |
Treatment | Animal’s Treated | 4 hr Post-treatment Mortality (n) | No Seizure Termination (n) | Seizure Termination (n) |
MDZ + PEG200 @ 20 Min | 17 | 1 (6%) | 16 (94%) | 0 (0%) |
MDZ + 15 mg/kg Retigabine @ 20 Min | 14 | 8 (57%) | 6 (43%) | 0 (0%) |
MDZ + 30 mg/kg Retigabine @ 20 Min | 12 | 3 (25%) | 1 (8%) | 8 (67%) |
30 mg/kg Retigabine @ 20 Min | 8 | 1 (12.5%) | 6 (75%) | 1 (12.5%) |
60 mg/kg Retigabine @ 20 Min | 14 | 3 (21%) | 1 (7%) | 10 (71%) |
MDZ + PEG200 @ 40 Min | 11 | 2 (18%) | 9 (82%) | 0 (0%) |
MDZ + 30 mg/kg Retigabine @ 40 Min | 15 | 3 (20%) | 3(20%) | 9 (60%) |