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. Author manuscript; available in PMC: 2022 May 21.
Published in final edited form as: Neuroscience. 2021 Apr 6;463:143–158. doi: 10.1016/j.neuroscience.2021.03.029

Table 1:

Summary of treatment mortality.

DFP Model Treatment Animal’s Treated 4 hr Post-treatment Mortality (n) 24 hr Post-treatment Mortality (n) Seizure Termination (n)
MDZ + PEG200 19 1 (5%) 0 N.E.
MDZ + 2 mg/kg Retigabine 16 0 0 N.E.
MDZ + 15 mg/kg Retigabine 21 1 (5%) 1 (5%) N.E.
MDZ alone 18 0 0 N.E.
15 mg/kg Retigabine 19 1 (5%) 0 N.E.
30 mg/kg Retigabine 7 4 (57%) 3 (43%) N.E.
Soman Model Treatment Animal’s Treated 4 hr Post-treatment Mortality (n) No Seizure Termination (n) Seizure Termination (n)
MDZ + PEG200 @ 20 Min 17 1 (6%) 16 (94%) 0 (0%)
MDZ + 15 mg/kg Retigabine @ 20 Min 14 8 (57%) 6 (43%) 0 (0%)
MDZ + 30 mg/kg Retigabine @ 20 Min 12 3 (25%) 1 (8%) 8 (67%)
30 mg/kg Retigabine @ 20 Min 8 1 (12.5%) 6 (75%) 1 (12.5%)
60 mg/kg Retigabine @ 20 Min 14 3 (21%) 1 (7%) 10 (71%)
MDZ + PEG200 @ 40 Min 11 2 (18%) 9 (82%) 0 (0%)
MDZ + 30 mg/kg Retigabine @ 40 Min 15 3 (20%) 3(20%) 9 (60%)