Figure 4. The proposed model of TACE-mediated EpCAM proteolytic processing, based on EpEX cleavage data.

(A) A Summary of experimental findings. The increased cleavage of the TYloop^mut compared to EpEX is indicated by three arrows. (B) The proposed model of EpCAM cleavage by TACE. Subunits in the EpEX and EpCAM dimers are colored pink and blue, except for the grey transmembrane region. Possible movement of EpEX subunits in the L264C and the destabilized EpCAM dimer is depicted with two positions of the pink subunit and a dashed line with arrows.