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. 2021 May 19;15:2129–2141. doi: 10.2147/DDDT.S303497

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© 2021 Wang et al.

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Probability of therapeutic target attainment (PTTA) with the four-dose regimens in the simulated patients with creatinine clearance (CrCL).

Notes: (A) CrCL of 40 mL/min. (B) CrCL of 80 mL/min. (C) CrCL of threefold of linezolid CL in the patients with normal renal function. PTTA was defined as the area under curve from 0 to 24h at steady-state divided by the minimum inhibitory concentration (AUC₂₄/MIC) >80, the percentage of time that plasma concentrations exceed the MIC (%T_>MIC >85%) and trough steady-state concentrations (C_ss,min) of linezolid (LNZ) <10 mg/L.