Table 2.
Population Pharmacokinetic Parameter Estimates of Linezolid in the Critically Ill Patients
| Parameters | Estimates | %RSE | Median by 1000 Bootstraps | 95% CI by 1000 Bootstraps |
|---|---|---|---|---|
| CL, L/h | 5.60 | 7.1 | 5.61 | 4.50–6.41 |
| V, L | 43.4 | 5.9 | 43.7 | 38.4–49.1 |
| θCrCL-CLa, b | 0.386 | 20.3 | 0.378 | 0.26–0.61 |
| CLINTER VAR, % | 63.9 | 8.9 | 63.9 | 48.6–69.1 |
| VINTER VAR, % | 17.6 | 44.5 | 19.1 | 11.1–25.6 |
| Additive error, mg/L | 0.055 | 56.1 | 0.041 | 0.01–1.27 |
| Proportional error, % | 36.2 | 8.8 | 36.0 | 20.6–42.8 |
Notes:
a
, CrCL is the creatinine clearance (mL/min). θCrCL-CL is the adjusting factor of the CrCL on the CL. bCockcroft and Gault formula for CrCL. 
, AGE is the age of the patient in years; WT is the body weight in kg; sCr (μM) is the serum creatinine concentration in μM.
Abbreviations: CI, confidence interval; CL, clearance of the central compartment; CLINTER VAR, the inter-individual variability of CL; V, the distribution volume of the central compartment; VINTER VAR, the inter-individual variability of V.