Table 2.

Summary of study combinations with associated nebuliser types, interfaces and breath patterns utilised for each test. (LFNT = Low Flow Nasal Therapy; HFNT = High Flow Nasal Therapy; Vt = tidal volume; RR = respiratory rate; BPM = Breath per minute; I:E = Inspiratory: Expiratory ratio; LPM = Litres per minute).

Simulated Aerosol Delivery Test Scenario	Nebuliser Type	Interface	Simulated Breath Parameters
Spontaneous breathing (SB)	VMN	Mouthpiece	Vt 410 mL RR 22 BPM I:E Ratio 1:2 [62,63]
	JN	Open facemask
Non-invasive patient intervention nasal oxygen	VMN	Nasal cannula with LFNT at 10 LPM
	VMN	Nasal cannula with HFNT at 60 LPM
Non-invasive ventilation (NIV)	VMN	Non-vented NIV mask
Invasive mechanical ventilation (IMV)	VMN	Endotracheal tube	Vt 550 mL RR 13 BPM I:E Ratio 1:2 [64]