Figure 7.

Sanguinarine dose-dependently represses human platelet spreading on the fibrinogen-coated surface and inhibits integrin αIIbβ3-mediated outside-in signaling. (a) A representative image of platelets spreading on the coated BSA or fibrinogen cover glasses. (b) The figure expressed the quantity of the single adherent platelet area as shown in the right panel, and the average coverage of the spreading platelets in five independent experiments. (c,d) Typical figure of phosphorylation of β3/Src of lysed spreading platelets for five independent experiments. The data had statistical significance at * p < 0.05 when compared to the control group.