Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic of sanguinarine antiplatelet activity. Sanguinarine attenuates collagen-induced platelet activation (including α and dense granule release) and thrombus formation by targeting the GPVI pathway (inhibiting the phosphorylation of Syk-PLCγ2 and PI3K-Akt-GSK3β), intracellular Ca2+ mobilization and integrin αIIbβ3-mediated “outside-in” signal transduction (inhibiting the phosphorylation of src). (Inhibit 
; Induce 
)
